complex fibroadenoma pathology outlines

Degnim AC, Frost MH, Radisky DC, Anderson SS, Vierkant RA, Boughey JC, Pankratz VS, Ghosh K, Hartmann LC, Visscher DW. "Fibroepithelial lesions with cellular stroma on breast core needle biopsy: are there predictors of outcome on surgical excision?". (Sep 2005). However, we cannot answer medical or research questions or give advice. document.write('') white/pale +/-hyalinization, typically paucicellular, compression of glandular elements with perserved myoepithelial cells, juvenile, complex, myxoid, cellular, tubular adenoma of the breast, well-circumscribed, rubbery, tan/white, +/-lobulated appearance, +/-short slit-like spaces, +/-calcifications. Complex fibroadenomas may increase the risk of breast cancer. An official website of the United States government. Epub 2015 Jan 13. Results: Approximately 16% of fibroadenomas are complex. .style2 {font-family: Arial, Helvetica, sans-serif} CD31, Also called pseudoangiomatous hyperplasia of mammary stroma, PASH is an incidental microscopic finding in up to 23% of breast surgical resections (, Almost always women who are premenopausal, Myofibroblastic origin, postulated role of hormonal factors (, Usually asymptomatic and an incidental finding but may be detected by imaging (, Histologic examination of resected tissue, May produce a mammographically detected mass, Nonneoplastic but mass forming lesion may rarely recur, especially in younger patients, 11 year old girl with bilateral nodular lesions (, 12 year old girl with pseudoangiomatous stromal hyperplasia (, 30 year old woman with pseudoangiomatous stromal hyperplasia of the breast with foci of morphologic malignancy (, 37 year old woman with giant nodular pseudoangiomatous stromal hyperplasia of the breast presenting as a rapidly growing tumor (, 46 year old woman with bilateral marked breast enlargement (, 67 year old man with pseudoangiomatous stromal hyperplasia of breast (, Local excision needed only in symptomatic mass forming lesions, If diagnosed on core needle biopsy, no surgical excision required, provided the diagnosis is concordant with radiologic findings (, Usually unilateral, well circumscribed, smooth nodule, Cut surface is firm, gray-white, lacks the characteristic slit-like spaces of fibroadenoma, Spaces are usually empty but may contain rare erythrocytes, Cellular areas or plump spindle cells may obscure pseudoangiomatous structure, No mitotic figures, no necrosis, no atypia, Fascicular PASH: cellular variant, in which myofibroblasts aggregate into fascicles with reduced or absent clefting, resembles myofibroblastoma, Moderately cellular with cohesive clusters of bland ductal cells (occasionally with staghorn pattern), single naked nuclei, some spindle cells with moderate cytoplasm and fine chromatin, Occasional loose hypocellular stromal tissue fragments containing spindle cells and paired elongated nuclei in fibrillary matrix (, Findings can confirm benign nature of disease but are nonspecific, resembling fibroadenoma or phyllodes tumor (, Finding plump spindled mesenchymal cells is suggestive (, Spaces are not true vascular channels but due to disruption and separation of stromal collagen fibers. They fall under the broad group of adenomatous breast lesions. 2022 May 17;19(10):6093. doi: 10.3390/ijerph19106093. National Library of Medicine Fibroepithelial tumours of the breast-a review. National Library of Medicine Semin Diagn Pathol. Int J Fertil Womens Med. They fall under the broad group of adenomatous breast lesions. Complex fibroadenomas are often smaller than simple fibroadenomas (1.3 cm compared with 2.5 cm in simple fibroadenomas). In particular, these mutations are restricted to the stromal component. This site needs JavaScript to work properly. 2001 May;115(5):736-42. doi: 10.1309/F523-FMJV-W886-3J38. This website is intended for pathologists and laboratory personnel but not for patients. Sat-Muoz D, Martnez-Herrera BE, Quiroga-Morales LA, Trujillo-Hernndez B, Gonzlez-Rodrguez JA, Gutirrez-Rodrguez LX, Leal-Corts CA, Portilla-de-Buen E, Rubio-Jurado B, Salazar-Pramo M, Gmez-Snchez E, Delgadillo-Cristerna R, Carrillo-Nuez GG, Nava-Zavala AH, Balderas-Pea LM. Giant juvenile fibroadenoma: a systematic review with diagnostic and treatment recommendations. Kuijper A, Mommers EC, van der Wall E, van Diest PJ. 1994 Jul 7;331(1):10-5. To determine the cytomorphological features of complex type fibroadenoma (CFA), we reviewed fine needle aspiration (FNA) cytology with correlation to its histopathology findings, and compared them with non-complex type fibroadenoma (NCFA). The key to breast pathology is the myoepithelial cell. 2003 Oct;12(5):302-7. doi: 10.1016/s0960-9776(03)00123-1. http://surgpathcriteria.stanford.edu/,